The main difference between a Metaverse with AI interacting with one another and humans in reality is that in the former, the entities interacting with each other are artificial intelligence, while in the latter, the entities interacting are human beings.

In a Metaverse with AI, the entities involved in the interactions are typically highly advanced and sophisticated AI systems, which are capable of learning, adapting, and making decisions on their own. These AI systems are able to interact with one another in a virtual world, and can engage in complex conversations, solve problems, and make decisions based on the information and data available to them.

In contrast, in reality, the entities interacting with one another are human beings, who have their own unique thoughts, feelings, and experiences. These interactions are typically more unpredictable and complex, as human beings are capable of a wide range of emotions and behaviors, and can be influenced by a variety of factors, such as their upbringing, culture, and personal experiences.

Overall, the main difference between a Metaverse with AI interacting with one another and humans in reality is the nature of the entities involved in the interactions. In a Metaverse with AI, the entities are artificial intelligence, while in reality, the entities are human beings.